The Daughters of the Nile maintains two permanent endowment funds to benefit Shriners Children’s® (formerly known as Shriners Hospital for Children®). In the United States, the Daughters of the Nile Foundation is a 501(c)(3) nonprofit public charity. In Canada, the Supreme Temple administers the Canadian Foundation.

Shriners Children’s® is a network of 22 hospitals throughout the United States, Canada, and Mexico that are renowned for providing the highest quality care to children with neuro-musculoskeletal conditions, burn injuries and other special healthcare needs within a compassionate, family-centered and collaborative care environment; providing for the education of physicians and other healthcare professionals; and conducting research to discover new knowledge that improves the quality of care and quality of life of children and families.